TRANSPLANTATION Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study

نویسندگان

  • Junya Kanda
  • Hiroh Saji
  • Takahiro Fukuda
  • Takeshi Kobayashi
  • Koichi Miyamura
  • Tetsuya Eto
  • Mineo Kurokawa
  • Heiwa Kanamori
  • Takehiko Mori
  • Michihiro Hidaka
  • Koji Iwato
  • Takashi Yoshida
  • Hisashi Sakamaki
  • Junji Tanaka
  • Keisei Kawa
  • Yasuo Morishima
  • Ritsuro Suzuki
  • Yoshiko Atsuta
  • Yoshinobu Kanda
چکیده

1Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan; 2Adult Stem Cell Transplant Program, Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC; 3HLA Laboratory, Kyoto, Japan; 4Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan; 5Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan; 6Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan; 7Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan; 8Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; 9Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan; 10Department of Medicine, Division of Hematology, Keio University School of Medicine, Tokyo, Japan; 11Department of Internal Medicine, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan; 12Department of Blood Transfusion, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima, Japan; 13Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan; 14Stem Cell Transplantation Center, Hokkaido University Hospital, Sapporo, Japan; 15Department of Haematology/Oncology, Osaka Medical Centre and Research Institute for Maternal and Child Health, Osaka, Japan; 16Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan; and 17Department of Hematopoietic Stem Cell Transplantation Data Management/Biostatistics, Nagoya University School of Medicine, Nagoya, Japan

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منابع مشابه

Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study.

To clarify which is preferable, a related donor with an HLA-1 Ag mismatch at the HLA-A, HLA-B, or HLA-DR loci in the graft-versus-host (GVH) direction (RD/1AG-MM-GVH) or an HLA 8/8-allele (HLA-A, HLA-B, HLA-C, and HLA-DRB1)-matched unrelated donor (8/8-MUD), we evaluated 779 patients with acute leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome who received a T cell-replete gra...

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Risk of relapse during the unrelated donor coordination period biases comparisons between allogeneic hematopoietic stem cell transplantation from an HLA 8 of 8 allele-matched unrelated donor (8/8 MUD) and that from a related donor with an HLA-1 antigen mismatch in the graft-versus-host (GVH) direction (RD/1AGMM-GVH). To reduce this bias, we performed a decision analysis focusing on acute myeloi...

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تاریخ انتشار 2012